Calibryo is a reproducible framework for measuring inter-observer variability in embryology assessment, designed to support laboratory quality systems without imposing external scoring standards.
It is a measurement framework designed to quantify inter-observer variability
in embryo assessment while preserving biological interpretability.
Calibryo does not define correctness. It measures agreement structure
within a cohort and makes variability visible for quality-management discussion.
Embryo morphology and time-lapse event annotation depend on trained human assessment. Inter- and intra-observer variability have been described in the embryology literature, particularly for morphology grading and developmental timing.
In routine laboratory practice, this variability is often discussed qualitatively but rarely measured systematically with a repeatable, exportable and auditable workflow.
Reference values are computed using a leave-one-out group reference
for each reviewer × item × video.
For time-based events, the reference is derived from the group distribution.
For ordinal or categorical items, comparison is performed according to predefined
item-specific logic.
The Reviewer Trajectory module adds a cross-campaign layer for monitoring reviewer behaviour over repeated calibration campaigns.
The current deployed dataset includes one real / demo-ready campaign state.
Longitudinal behaviour cannot yet be clinically validated from a single campaign.
Simulated trajectory points may be used for interface evaluation and product demonstration,
but they are explicitly separated from real data and must not be interpreted as clinical results.
Calibryo complements time-lapse workflows by focusing on the reliability of human annotation. It does not compete with embryo selection tools; it supports reproducibility of the assessment process.
Full workflow demonstration: Admin setup, secure reviewer app, reporting pipeline, dashboard interpretation and Reviewer Trajectory module.